Deconvolution and compensation of MS interferences

For many gas species (e.g., He, Ar, Kr, N2, O2, CO2) the partial pressures measured with the miniRUEDI can usually be calibrated by simple peak-height comparison relative to ambient air or gas standard with well known partial pressures. However, depending on the composition of the analysed gases, the ion currents measured at certain m/z ratios may result from overlapping ion currents of multiple species (for example CH4, O2 and N2 at m/z=15 and 16; or Ne, Ar and H2O at m/z=20).

We developed a method that extends the miniRUEDI peak-height comparison in order to resolve such overlap interferences. The method uses spectral deconvolution and was incorporated in the ruediPy software toolbox. The deconvolution method substantially improves the analytical accuracy in situations where mass-spectrometric interferences cannot be avoided.

Full details are availalble in the original publication: M.S. Brennwald, Y. Tomonaga, R. Kipfer: Deconvolution and compensation of mass spectrometric overlap interferences with the miniRUEDI portable mass spectrometer, MethodsX, 2020, doi: 10.1016/j.mex.2020.101038